PsychosisBank English Palaniyappan TOPSY Corpus

Lena Palaniyappan Centre of Excellence in Youth Mental Health McGill University lena.palaniyappan@mcgill.ca

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In accordance with TalkBank rules, any use of data from this corpus must be accompanied by at least one of these references:

Dalal TC, Liang L, Silva AM, Mackinley M, Voppel A, Palaniyappan L. Speech based natural language profile before, during and after the onset of psychosis: a cluster analysis. Acta Psychiatrica Scandinavica. 2025 Mar;151(3):332-47.

MacKinley M, Ford SD, Jeon P, Théberge J, Palaniyappan L. Central oxidative stress and early vocational outcomes in first episode psychosis: a 7-tesla magnetic resonance spectroscopy study of glutathione. Schizophrenia Bulletin. 2022 Jul 1;48(4):921-30.

The Pathophysiology of Thought Disorder in Psychosis (TOPSY)

This is a longitudinal study relating thought disorder, brain structure/function, and clinical outcomes in patients referred to the Prevention and Early Intervention in Psychoses Program (PEPP, London Ontario) who are at different stages of psychosis – high-risk, untreated first episode and >3 years of illness, as well as healthy controls. This study collected picture description speech data at 2 time points, Thought and Language Index scores, PANSS-8, Calgary Depression Scale scores as well as verbal fluency, modified digit symbol substitution test and Trail Making Test (B). 7 tesla MRI (structural, resting functional and glutamate spectroscopy from anterior cingulate cortex), social and occupational outcomes by 12 months (including educational status), DSM-5 diagnosis by consensus at 6-12 months and self-endorsed substance use data at baseline are also available.